Blar i forfatter "Büchner, Jochen"

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    • Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma 

      Henriksen, Jørn Remi; Haug, Bjørn Helge; Büchner, Jochen; Tømte, Ellen; LØkke, cecilie; Flaegstad, Trond; Einvik, christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Background: Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggressive metastatic tumours with poor prognosis. Amplification of the MYCN oncogene is a well established poor prognostic factor found in up to 40% of high risk neuroblastomas. Using ...

    • MYCN and microRNAs in neuroblastoma 

      Büchner, Jochen (Doctoral thesis; Doktorgradsavhandling, 2011-09-30)
      Neuroblastoma is the most common extra-cranial solid tumor in childhood. Tumors with amplification of the MYCN proto-oncogene are characterized by aggressive biology and poor survival of the patients. To improve future treatment options, it is of fundamental interest to understand MYCN’s role in tumorigenesis and determine factors regulating MYCN expression. In this thesis focuses on the interactions ...